Pyrazinamide: an Effective Agent for the Treatment of Leishmaniasis Leishmaniasis is a disease that has been neglected by most of the developed world until now, despite the fact that it is the 2nd most prevalent parasitic disease after malaria in global disease burden. Formerly considered to be a tropical disease, infections are now emerging in general populations across Europe, North America and Austral-Asia. It’s... Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > University at Albany
Proprietary Doxorubicin Formulation Increases Survival and Safety Over Free Doxorubicin and Doxil Doxorubicin (DOX) is a commonly used anticancer chemo drug, and its clinical use is associated with dose-limiting cardiotoxicity. It is used to treat a wide variety of cancers including leukemia, bone and Karposi sarcomas, multiple myeloma, and ovarian, breast, kidney, endometrial, liver and gastric cancers. Despite being a generic, the market for liposomal... Category(s): Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Campus > Upstate Medical University
6-Mer Peptide for Anti-Cancer Therapeutic Use A 6-mer peptide (Win6mer) has been designed which has potential as an anti-cancer therapeutic. The Win6mer disrupts MLL1 and SETd1A core complex assembly, but does not inhibit isolated SET domain activity. MLL I belongs to the SETI family of histone H3 lysine 4 (H3K4) methyltransferases, comprised of MLLl-4 and SETdlA/B. MLLl translocations are present... Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Campus > Upstate Medical University
Process of Treating Myopia by Modulating Retinal Signaling Pathways Underlying Retinal Response to Positive and Negative Optical Defocus Myopia (nearsightedness) is the most common eye disorder, and is rapidly becoming one of the leading causes of blindness. At the current rate of myopia occurrences, more than half the population will be myopic by 2050. While myopia has already increased from effecting 25% of the U.S. to 58% as of 2014, over 80% of the populations of urban communities... Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines, Campus > SUNY College of Optometry
Mechanisms of Action of an Aqueous Extract of the Bark of a Plant Used to Treat Diabetes in the Democratic Republic of Congo This processes extracts the bark of Musanga cecropioides and processes the bark into powder which can be administered to patients suffering from diabetes. The powder decreases fasting and post prandial hyperglycemia. Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > SUNY Oswego
A constituent purified from plant Arctium Lappa L as a novel cancer therapeutic In the United States there were more than 1.5 million new diagnosed cancer cases, and approximately 577,000 cancer-related deaths in the U.S. in 2012, according to the American Cancer Society. The development and discovery of newer anticancer therapeutics are still urgently needed. For the past four decades, cancer treatments have commonly been derived... Category(s): Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
SHIP1 Inhibitors to Augment Blood Cell Production and Transplantation and Kill Cancer Cells SUNY Upstate Medical University researchers have developed a class of small molecule compounds that show promise for treating multiple myeloma and myelosuppression that occurs with many cancer treatments. These drugs inhibit a gene called SHIP1 — a novel target in cancer treatment — and have been shown to kill cancer cells in the lab and extend... Category(s): Technology Classifications > Biological Materials, Technology Classifications > Therapeutics and Vaccines
Rationally Designed Aromatase Inhibitors as Anti-Breast Cancer Agents We have developed exemestane-based vinyl diazo compounds that act as aromatase inhibitors to be used in the treatment of cancer, particularly breast and ovarian cancer. Exemestane is structurally related to androstenedione and acts as an irreversible, steroidal aromatase inactivator. Our aromatase inhibitors are based upon the steroid scaffold... Category(s): Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Drug Delivery
Nanosphere Delivery System for the Treatment of Spinal Cord Injury SUNY Upstate Medical University researchers have developed a controlled-released treatment for delivering a nerve repair drug precisely to areas of damage. With traumatic spinal cord injury or the neurodegenerative disease multiple sclerosis, demyelination of nerve cells lead to loss of motor function. The compound chondroitinase (cABC) boosts the... Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Drug Delivery, Technology Classifications > Nanotechnology
Method for the Treatment of Attention Deficit/Hyperactivity Disorder (ADHD) Using Sodium Hydrogen Exchange Inhibitors The Problem: According to the Center for Disease Control, nearly 10% of children in the United States will be diagnosed with ADHD at some point. In 2007, there were 2.7 million children with an active diagnosis receiving medication to treat ADHD. Currently, the primary medications used to treat ADHD are central nervous system stimulants, with... Category(s): Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines

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